Nitrazepam has become affiliated with intense hepatic disorders, comparable to other nitrobenzodiazepines. Nitrobenzodiazepines which include nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more harmful to the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which can result in cytotoxicity.The 50 %-l